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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAMTS5 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5, ADAM Metallopeptidase with Thrombospondin Type 1 Motif 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, A Disintegrin and Metalloproteinase with Thrombospondin Motifs 11, ADAMTS11, ADAM-TS 11, AD

Anti -ADAMTS5 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5, ADAM
Metallopeptidase with Thrombospondin Type 1 Motif 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, A
Disintegrin and Metalloproteinase with Thrombospondin Motifs 11, ADAMTS11, ADAM-TS 11, AD

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal Human tissues. ESTs have been isolated from Human tissue libraries, including normal breast, embryo and heart and cancerous placenta and uterus.
Catalog #A0859-61B1
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 3ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman Cartilage
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human ADAMTS5.
SpecificityRecognizes human ADAMTS5.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesEC=3.4.24.-


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