Anti -ADAMTS5, NT (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5,
ADAM-TS 5, ADAM-TS5, ADAMTS-5, A Disintegrin and Metalloproteinase with Thrombospondin
Motifs 11, ADAM-TS 11, ADAMTS-11, ADMP-2, Aggrecanase-2, ADAMTS11, ADMP2)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
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| ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. | | | Catalog # | A0859-61C2 | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 14ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to 20aa from N-terminus of human ADAMTS5. | | Specificity | Recognizes human ADAMTS5. Species sequence homology: gorilla (100%), gibbon (100%), monkey (95%), marmoset (95%), panda (85%), porcine (85%), rat (80%), bovine (80%). | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -ADAMTS5, NT (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5, ADAM-TS 5, ADAM-TS5, ADAMTS-5, A Disintegrin and Metalloproteinase with Thrombospondin Motifs 11, ADAM-TS 11, ADAMTS-11, ADMP-2, Aggrecanase-2, ADAMTS11, ADMP2) |
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