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You are here:Home » Antibodies » Antibodies-Matrix Metalloproteinases » Anti -ADAMTS13 (A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13)

Anti -ADAMTS13 (A disintegrin-like and metalloprotease (reprolysin type) with
thrombospondin type 1 motif, 13)


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Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E B IP
ADAMTS13 (A disintegrin and metalloprotease with TSP motifs 13) is a 140-230kD, secreted glycoprotein member of the ADAMTS family of proteases. ADAMTS13 is produced by the liver and circulates in plasma where it cleaves and reduces the activity of von Willebrand factor. ProADAMTS13 is 1398aa in length. It contains a 45aa prodomain (aa30-74), one peptidase domain (aa80-286) and one disintegrin (aa287-383) domain, multiple TSP regions and two CUB domains. The prodomain does not affect activity, while the TSP and CUB domains appear to be necessary for activity. One truncated form exists that shows truncation after Gln448. Over aa34-688, human ADAMST13 shares 76% aa identity with mouse ADAMST13.
Suitable for use in ELISA, Western Blot, and Immunoprecipitation. Other applications not tested.
Catalog #A0859-61F2
Recommended DilutionWestern Blot: 0.1ug/ml using recombinant human ADAMTS13
Immunoprecipitation: 25ug/ml using conditioned cell culture medium spiked with recombinant human full length ADAMRT13
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
FormSupplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenCHO cell-derived, recombinant human ADAMTS13 isoform aa34-688.
SpecificityRecognizes human ADAMTS13.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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