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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAMTS13 (A Disintegrin-like and Metalloprotease (reprolysin type) with Thrombospondin type 1 motif)

Anti -ADAMTS13 (A Disintegrin-like and Metalloprotease (reprolysin type) with
Thrombospondin type 1 motif)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates at least four transcript variants encoding different isoforms.
Catalog #A0859-61Z
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:100-1:1,000.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormAs reported
PuritySerum
ImmunogenA synthetic peptide which maps to a region between residues 250 and 350 of human A Disintegrin-like and Metalloprotease (reprolysin type) with Thrombospondin type 1 motif, 13 using the numbering given in entry XP_088414.1 (GeneID 11093).
SpecificitySpecific for human ADAM TS13 protein. Shown to react with purified recombinant ADAM-TS13. It has not been tested for reactivity with ADAM-TS13 from native sources. Species Crossreactivity: Human. Other species not tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesvon Willebrand Factor-Cleaving Protease, vWF-Cleaving Protease, vWF-CP


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