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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -ADAMTS15 (A Disintegrin And Metalloproteinase With Thrombospondin Motifs 15, ADAM-TS 15, ADAM-TS15, ADAMTS-15)

Anti -ADAMTS15 (A Disintegrin And Metalloproteinase With Thrombospondin Motifs 15, ADAM-TS
15, ADAM-TS15, ADAMTS-15)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IH FC
A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15) is a secreted multi-domain protease that is primarily expressed in fetal liver and kidney. ADAMTS1, 4, 5, 8, and 15 form a subfamily of ADAMTS proteases that possess aggrecanase activity. These proteins are synthesized as zymogens which have a pro-domain that is removed by furin-like protein convertases. ADAMTS15 functions as a suppressor of tumor growth and invasion. It is downregulated in colon cancer, and its expression in breast cancer correlates with poor prognosis. Within aa18-682 (which includes the propeptide, peptidase, disintegrin, first TSP-1 and most of the Cys-rich domain), human ADAMTS15 shares 95% aa sequence identity with mouse and rat ADAMTS15.
Catalog #A0859-64
ApplicationsSuitable for use in Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionFlow Cytometry: 2.5ug labels 10e6 cells
Western Blot: 2ug/ml
Immunohistochemistry: 8-25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2B
Clone No11n2
HostMouse
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml.
PurityPurified by Protein A/G affinity chromatography.
ImmunogenRecombinant corresponding to aa18-682 from human ADAMTS15 expressed in CHO cells (Q8TE58).
SpecificityRecognizes human ADAMTS15. Species sequence homology: Mouse and rat (95%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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