Adefovir is a more toxic analog of Tenofovir. Also, it is used with entecavir as similar efficacy in treating chronic hepatitis B. An acyclic phosphonate nucleotide analog of dAMP. Has anti-viral activity against HIV-1 and HBV by inhibiting reverse transcriptase and polymerase activity, respectively. Demonstrates improved antiviral activity when combined with other HBV drugs.
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