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You are here:Home » Antibodies » Abs to Receptors » Anti -Adenosine A2a Receptor (A2aR)

Anti -Adenosine A2a Receptor (A2aR)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IH
Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The A2aAR is a glycoprotein that can activate adenylyl cyclase via Gs interactions. Stimulation of A2aAR and the resultant accumulation of cAMP inhibits platelet aggregation and in certain vascular beds is associated with vasodilation and drop in blood pressure. A2aAR is reported to interact with D2 dopamine receptor sites in the brain where they co-express (striatum, olfactory tubercle and nucleus accumbens). Other tissues including heart, kidney, and lung also express A2aAR.
Catalog #A0869-56A1
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 1:1000 detects an ~45kD protein from canine striatum representing A2aAR.
Immunohistochemistry (paraffin-embedded sections): 1:100. Staining of A2aAR in human hippocampus yeilds a pattern consistent with plasma memrane staining.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceCanine
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa 373-391, ESHGDMGLPDVELLSHELK, of canine Adenosine Receptor A2a. Cellular Localization: Cell Membrane.
SpecificityRecognizes canine adenosine receptor A2a at ~45kD. Does not detect other AR subtypes. Species Crossreactivity: human
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesADORA2A, HGNC:263, RDC8, hA2aR, Adenosine Receptor Subtype A2a


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