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You are here:Home » Antibodies » Abs to Receptors » Anti -Adenosine A2a Receptor (A2aR)

Anti -Adenosine A2a Receptor (A2aR)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
The purine nucleoside adenosine modulates diverse physiological functions including induction of sedation, vasodilatation, suppression of cardiac rate and contractility, neurotransmitter release, inhibition of platelet aggregation and lipolysis. Adenosine released from cells interacts with membrane receptors (adenosine receptors, ARs). Based upon, biochemical and pharmacological criteria, AR s have been classified into A1, A2a, A2b , and A3 . The high affinity receptor A1 inhibits adenyl cyclase, whereas low affinity receptor A2a stimulates the cyclase via G proteins. A2a receptor is believed to cause vasorelaxation in coronary artery. Various, ARs and their subtypes have recently been cloned from several species. ARs belong to the superfamily of G-protein coupled receptors and predicted to contain 7 transmembrane domains. The N-termini are predicted to be extracellular and the C-termini cytoplasmic. There is an overall 30% homology among the four ARs. ARs are distributed throughout the body. Gene location of various ARs: A1 (Chromosome 1; q.31.3-32.2); A2a (Chromosome 22); A2b (Chromosome 17; p.11.2-12); A3 (Chromos.1).
Catalog #A0869-57
Application(s)
Immunohistochemistry with formalin fixed paraffin embedded tissues. Not tested for other uses.
Recommended DilutionImmunohistochemistry: ~32 ug/ml
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.01% sodium azide.
PurityAffinity purified sera
ImmunogenSynthetic peptide [KLH conjugated] made to the C-terminus.
SpecificitySpecies Reactivity: Human. There is 69/94% identity/homology to rat and 69/94% identity/homology to mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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