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You are here:Home » Antibodies » Abs to Infectious Disease Adenovirus » Anti -Adenovirus, multiple clones

Anti -Adenovirus, multiple clones

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Highly Purified B IP IH IF
The early region (E1A) of the adenovirus genome plays a central role in cellular transformation and regulation of gene expression. The adenovirus early gene product E1A is a potent stimulator of cellular proliferation, which when overexpressed can overcome the growth-inhibitory effects of TGF-beta. The E1A region encodes a series of related proteins (35-46kDa) with multifuctional capabilities and form a specific complex with the retinoblastoma tumor suppressor gene product (Rb protein). The E1A and E1B regions together comprise the transforming region of adenovirus. While expression of E1A alone is sufficient to immortalize primary cells, complete transformation requires the additional expression of the E1B region. Several conserved regions of E1A are similar to portions of other viral oncoproteins like the HPV-16 and HPV-18 E7 and SV40 large T antigen.
Catalog #A0878
Applications Immunofluorescence, Immunoprecipitation, Western Blot, Immunohistochemistry (frozen & formalin/paraffin). Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min, followed by cooling at RT for 20 min.
Recommended DilutionImmunoprecipitation: Use Protein A; 2ug antibody/mg protein lysate)
Western Blotting: 1ug/ml
Immunohistochemistry: 2-4ug/ml
Optimal dilutions to be determined by the researcher.
Clone TypeMonoclonal
IsotypeIgG2a,k
Clone No0.N.8+ 0.N.7
HostMouse
Concentration200ug/ml
FormSupplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 15mM sodium azide.
Also available without BSA and azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenAdenovirus
SpecificitySpecies Reactivity: Adenovirus
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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