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You are here:Home » Antibodies » Abs to Receptors » Anti -Adiponectin Receptor 1 (AdipoR1, CGI-45)

Anti -Adiponectin Receptor 1 (AdipoR1, CGI-45)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IF
The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha (PPARA) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. ADIPOR1 and ADIPOR2 are highly related structurally, and mouse Adipor1 and Adipor2 share 66.7% identity. ADIPOR1 and ADIPOR2 are 7-transmembrane domain proteins, but they are structurally, topologically, and functionally distinct from G proteincoupled receptors (GPCRs). The mouse, human, and rat Adipor1 protein (ADIPOR1) contains 375 amino acids (with a predicted MW of 42.4 kD). Human and mouse ADIPOR1 have 96.8% homology. ADIPOR1 has high-affinity receptor for globular adiponectin (gACRP30) but low-affinity receptor for full-length adiponectin. ADIPOR1 is widely expressed. It is highly expressed in skeletal muscle. It is expressed at intermediate levels in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. It is weakly expressed in colon, thymus and small intestine.
Catalog #A0886-75C
ApplicationsSuitable for use in Western Blot, Immunofluorescence and ELISA. Other applications not tested.
Recommended DilutionsWestern Blot: 1-10ug/ml using ECL
ELISA: 0.5-1ug/ml. Use 1ug/ml of control peptide to coat ELISA plates.
Immunofluorescence: 2-20ug/ml
Optimal dilutions to be determined by the researcher.
Control PeptideA0886-75E: Adiponectin Receptor 1, Mouse, Control Peptide
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, 0.1% BSA. Reconstitute with 100ul sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to 18aa from the C-terminus, extracellular domain of mouse ADIPOR1, conjugated to KLH. Species Sequence Homology: Green puffer, porcine, duck, chicken, rat, bovine, 100%; human, chimp, frog, and zebra fish, 94%.
SpecificityRecognizes mouse Adiponectin Receptor 1. No significant sequence homology is seen with ADIPOR2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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