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You are here:Home » Antibodies » Abs to Receptors » Anti -Adiponectin Receptor 2 (ADIPOR2, ACDCR2, Adiponectin Receptor Protein 2, FLJ21432, MGC4640, PAQR2, Progestin and AdipoQ Receptor Family Member II)

Anti -Adiponectin Receptor 2 (ADIPOR2, ACDCR2, Adiponectin Receptor Protein 2, FLJ21432,
MGC4640, PAQR2, Progestin and AdipoQ Receptor Family Member II)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH IF
Acrp30 (adipocyte complement-related protein of 30kD), also known as AdipoQ, APM1, Adiponectin, Gelatin binding protein 28kD/GBP28 or adipocyte most abundant gene transcript) was identified as a novel adipocyte-specific synthesized and secreted protein with structural resemblance to complement factor C1q. Like adipsin, Acrp30 secretion is induced ~10-fold during adipocyte differentiation. Plasma levels are reduced in obese humans, and low levels are associated with insulin-resistance. Treatment of db/db mice with TZD increased Acrp30 levels. Acrp30 is proteolytically cleaved at 104 aa to generate the globular Acrp30 (gAcrp30). Administration of gAcrp30 into mice fed a diet high in fat and sugar caused substantial weight loss. A marked reduction in plasma triglycerides, glucose, and free fatty acids was attributed due in part to increased fatty acid oxidation by muscle. Full length Acrp30 was less potent than gAcrp30. Adiponectin receptor 2/ADIPOR2, a 311-aa protein (mouse) with a MW of 35.4kD and human ADIPOR2 has 299aa. The ADIPOR2 serves as receptor for globular and full-length adiponectin and mediates increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. ADIPOR2 is most abundantly expressed in Liver.
Applications:
Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence and Western Blot. Other applications not tested.
Catalog #A0886-80C
Recommended DilutionsWestern Blot: 1-10ug/ml (ECL)
ELISA: 0.5-1ug/ml Using control peptide to coat plates at 1ug/ml
Immunohistochemistry: 2-20ug/ml.
Immunofluorescence: 2-20 ug/ml
Optimal dilution determined by the researcher.
Recommended Control PeptideA0886-80D: Adiponectin Receptor 2, Mouse, Control Peptide
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a lyophilized powder from PBS, 0.1% BSA. Reconstitute with 100ul sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 14aa from the C-terminal, extracellular domain region of mouse ADIPOR2 conjugated to KLH.
SpecificityRecognizes mouse Adiponectin Receptor 2. Species Sequence Homology: rat; 100%; bovine, chimp and human; 92% and porcine; 85%. No significant sequence homology is seen with ADIPOR1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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