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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -ADNP (Activity Dependent Neuroprotective Protein)

Anti -ADNP (Activity Dependent Neuroprotective Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified IH
ADNP (Activity-dependent neuroprotective protein-1) is a member of a small family of VIP-induced neurotrophic factors. Although its predicted MW is 124kD, it runs anomalously at 150kD in SDS-PAGE. ADNP is known to be expressed by endothelium, astrocytes, neurons, macrophages, monocytes and B cells, and serves to down-regulate inflammation in immune cells, while acting to promote neuronal survival in response to stress or injury. Human ADNP is 1102aa in length. It has no definitive signal sequence, but is reported to be found both extracellularly and intracellularly, where it shuttles between cytoplasm and nucleus. Full-length ADNP contains nine consecutive C2H2-type zinc finger regions (aa74-686), followed by a DNA-binding homeobox domain (aa754-814). There are 12 utilized phosphoserine sites, two C-terminal acetylated lysines, an NLS (aa716-733), an NES (aa788-804) and one NAPVSIPQ (NAP) motif (aa354-361) that likely mediates the ADNP neuroprotective function. Over aa941-1102, human ADNP shares 93aa identity with mouse ADNP.
Catalog #A0901-01D
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: 5-15ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationNot determined
FormSupplied as a lyophilized powder in PBS, Trehalose. Reconstitute with sterile PBS to 200ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant corresponding to aa941-1102 from human ADNP expressed in E. coli (Q9H2P0).
SpecificityRecognizes human ADNP. Species sequence homology: Recombinant mouse ADNP (15%).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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