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Anti -ADPN (Adiponutrin, Patatin-like Phospholipase Domain containing 3)
Anti -ADPN (Adiponutrin, Patatin-like Phospholipase Domain containing 3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Adiponutrin is one of three recently identified adipocyte lipases. Surprisingly, these proteins also retain transacylase activity, a hitherto unknown pathway of triacylglycerol synthesis in the adipocytes. This may enable them to participate in both anabolic and catabolic processes. The adiponutrin gene (ADPN) is downregulated by fasting and upregulated by refeeding, suggesting a role in lipogenesis. Experiments in human adipocytes confirmed that the gene is upregulated in response to insulin in a glucose-dependent fashion. Obese subjects had increased levels of subcutaneous and visceral abdominal adipose tissue ADPN mRNA. Visceral ADPN mRNA expression was correlated to measures of insulin sensitivity (fasting insulin and homeostasis model assessment). | | | Catalog # | A0901-25 | | Genbank accession Number | BC014449 | | Alternative Symbols: PNPLA3,iPLA(2)epsilon | | Calculated Molecular Weight: 481aa,53kD | | Observed Molecular Weight: 53kD | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1: 1000-1: 100,000 | | Western Blot: 1: 100-1: 1000. | | Optimal dilution determined by the researcher | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide., 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant human ADPN. | | Specificity | Recognizes human ADPN (Adiponutrin,Patatin-like Phospholipase Domain containing 3) at 53kD. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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