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You are here:Home » Antibodies » Antibodies-Enzymes, Phospholipase » Anti -ADPN (Adiponutrin, Patatin-like Phospholipase Domain containing 3)

Anti -ADPN (Adiponutrin, Patatin-like Phospholipase Domain containing 3)


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Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
PPNPLA3(patatin-like phospholipase domain-containing protein 3), also named as ADPN, C22orf20, alternatively referred to as adiponutrin, encodes a 481-amino acid protein of 54 kD that belongs to the patatin-like phospholipase domain-containing family. Despite the apparent absence of a membrane-spanning domain, PNPLA3 is tightly associated with membranes and it may be targeted specifically to regions of the ER membrane that are destined to become nascent lipid droplets (PMID:22338072). It is a multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). It has 2 isoforms produced by alternative splicing
Catalog #A0901-25
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:200-1:1000
Optimal dilution determined by the researcher
Positive ControlsHepG2 cells, human adipose tissue and Jurkat cells
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in PBS, pH 7.3, 0.1% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenPNPLA3 fusion protein ag1959
SpecificityRecognizes human ADPN at ~53kD.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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