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Anti -ADPN (Adiponutrin, Patatin-like Phospholipase Domain containing 3)
Anti -ADPN (Adiponutrin, Patatin-like Phospholipase Domain containing 3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Sheep |
Affinity Purified |
E B IH |
|
| Human ADPN (Adiponutrin; also PNPLA3 and patatin-like phospholipase domain-containing protein 3) is a 53kD member of the PNPLA family of phospholipase A2 enzymes. It is expressed in white adipocytes. Adiponutrin is elevated in response to insulin and appears to act not as a phospholipase, but a molecule involved in anabolic pathways. ADPN is likely to be a type II transmembrane protein that is 481aa in length. It contains one patatin domain (aa10-179) that | | | is associated with in vitro enzyme activity and a transmembrane segment between | | | aa42-62. There appear to be two splice variants. One shows a four aa deletion of aa59-62 and a second shows an alternate start site at Met379. Over aa 160-349, human ADPN shares 61% aa identity with mouse Adiponutrin. | | | | | | Applications: | | | Suitable for use in ELISA, Western Blot, and Immunohistochemistry. Other applications not tested. | | | Catalog # | A0901-25A | | Recommended Dilution | ELISA: 0.5-1.0ug/ml | | Western Blot: 1.0ug/ml | | Immunohistochemistry: 10ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Sheep | | Source | Human | | Concentration | ~0.2mg/ml | | Form | Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute with 40-50% glycerol, PBS. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant human ADPN, aa160-349 (E. coli). | | Specificity | Recognizes human ADPN. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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