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You are here:Home » Antibodies » Abs to Receptors » Anti -Adrenergic Receptor, beta 1 (B1AR)

Anti -Adrenergic Receptor, beta 1 (B1AR)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.
Catalog #A0906-87A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionPeptide ELISA: 1:128,000
Western Blot: 0.3-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH 7.3. 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to ESDEARRCYNDPK, representing the internal regionof the human protein according to NP_000675.1.
SpecificityRecognizes human ADRB1. Species Crossreactivity: mouse, rat and canine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesADRB1, ADRB1R, BETA1AR, RHR, beta-1-Adrenergic Receptor


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