| b2-Adrenergic receptor is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This protein contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. |
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| Catalog # | A0906-88B |
| Applications | Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. |
| Recommended Dilution | Western Blot: 1:2000 |
| Immunohistochemistry: 1:200 |
| Optimal dilutions to be determined by the researcher. |
| Recommended Secondary Antibodies | I1906: IgY, Chicken Pab Rb x Ch |
| I1906-10: IgY, Chicken (HRP) Rb x Ch |
| I1906-12: IgY, Chicken (FITC) Rb x Ch |
| I1906-14: IgY, Chicken (AP) Rb x Ch |
| Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
| CAS Number | n/a |
| Clone Type | Polyclonal |
| Isotype | IgY |
| Host | Chicken |
| Source | Human |
| Concentration | ~1mg/ml |
| Form | Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide. |
| Purity | Purified by affinity chromatography. |
| Immunogen | Recombinant protein corresponding to aa335-408, DFRIAFQELLC LRRSSLKAYGN GYSSNGNTGE QSGYHVEQEKE NKLLCEDLPGT EDFVGHQGTVP SDNIDSQGRNCS T, of human beta 2 Adrenergic Receptor (NP_000015.1). Cellular Localization: Cell Membrane |
| Specificity | Recognizes human Beta 2 Andrenergic Receptor at ~46.5kD. |
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| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
| Alternate names | ADRB2, Adrenergic, beta-2-, Receptor, Surface [Homo sapiens], HGNC:286, ADRB2R, ADRBR, BAR, BETA2AR, beta-2 Adrenergic Receptor, beta-2 Adrenoceptor, Catecholamine Receptor |
