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You are here:Home » Antibodies » Abs to Receptors » Anti -Adrenergic Receptor, beta 2 (Beta-2 Adrenergic Receptor, Beta-2 Adrenoreceptor, Beta-2 Adrenoceptor, ADRB2, ADRB2R, B2AR)

Anti -Adrenergic Receptor, beta 2 (Beta-2 Adrenergic Receptor, Beta-2 Adrenoreceptor,
Beta-2 Adrenoceptor, ADRB2, ADRB2R, B2AR)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E FC
The b-adrenoceptors can be divided into b1, b2, b3 and b4-adrenoceptors defined in terms of agonist potencies, b2-adrenoceptors displayed a higher selectivity for nor-adrenaline than for adrenaline. B2-receptors are mainly postsynaptic and are located on a number of tissues including blood vessels, bronchi, GIT, skeletal muscle, liver and mast cell. Activation results in vasodilatation, bronchodilation, relaxation of the GIT, glycogenolysis in the liver, tremor in skeletal muscle and inhibition of histamine release from mast cells. Transduction is via G-proteins coupled to the intracellular second messenger adenylate cyclase. B-receptors are positively coupled to adenylate cyclase via activation of Gs G-protein, however activation of the b2-adrenoceptors results in stimulation and inhibition of adenylate cyclase. The b2-receptor selective agonists are widely used in the treatment of asthma and other related bronchospastic conditions. They are commonly used in the treatment of angina pectoris, cardiac arrhythmia and for the long-term treatment of patients who survive myocardial infarction. B-receptor antagonists have also been used as anti-hypertensive for a number of years. Beta-blockers have also proven useful in the treatment of conditions such as migraine, anxiety disorders, hyperthyroidism, alcohol withdrawal and when applied topically are useful in the treatment of glaucoma and ocular hypertension.
Catalog #A0906-89
ApplicationsSuitable for use in Flow Cytometry, ELISA and Functional Assays. Other applications not tested.
Recommended DilutionFlow Cytometry: A431 human epidermoid cells in suspension for 1h at 4°C in PBS containing monoclonal antibody (260nM). After 1h of incubation, the cells were fixed with 2% formaldehyde
Functional Assays: functions as an agonist in neonatal rat cardiomyocytes. Furthermore, Fab fragments of agonist-like antibody 6H8 behave as antagonist
Optimal dilutions to be determined by the researcher.
Positive Control Human epidermoid carcinoma cell A431 line
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No13A16
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, 0.1% BSA.
PurityPurified by Protein G affinity chromatography.
ImmunogenFree peptide Beta2-H19C
SpecificityRecognizes human Beta2-adrenoceptor. Species Crossreactivity: rat and guinea pig.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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