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You are here:Home » Antibodies » Abs to G Protein Receptors » Anti -Adrenergic Receptor Kinase, beta 1, phosphorylated (Ser670) (bARK1, B1 AR, ARK1 beta, G-Protein Coupled Receptor Kinase 2, GPCR K2, GRK2)

Anti -Adrenergic Receptor Kinase, beta 1, phosphorylated (Ser670) (bARK1, B1 AR, ARK1
beta, G-Protein Coupled Receptor Kinase 2, GPCR K2, GRK2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
GRK2, one of six members of this family that have been identified, is ubiquitously expressed in mammals. After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs (e.g., b2-adrenergic receptor) are phosphorylated by GRKs. Internalization of the GPCRs, regulated by b-arrestin-1, leads to activation of the Ras Raf ERK1&2 signaling pathway. GRK2 activity is tightly controlled by different mechanisms including phosphorylation by kinases such as PKC, Src and ERK1&2, as well as interaction with various proteins. ERK phosphorylates and thus inactivates GRK2 on serine 670 in a negative feedback mechanism.
Catalog #A0906-96
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.1-1 ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlPC12 and CHO-K cells.G protein-coupled receptor kinases (GRKs) are important regulators of G protein-coupled receptors (GPCRs).
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human GRK2 that contains serine 670. Species sequence homology: rat, hamster and bovine.
SpecificityRecognizes human GRK2 when phosphorylated at Ser670. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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