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Anti -Advanced Glycosylation Endproduct (AGE, CML, Carboxymethyllysine)
Anti -Advanced Glycosylation Endproduct (AGE, CML, Carboxymethyllysine)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| N-epsilon carboxymethyllysine (CML) is formed by the non enzymatic Schiff base reaction of glucose with proteins, followed by an Amadori rearrangement and oxidation that leaves only a carboxymethyl group attached to the lysine. The levels of CML adducts accumulate over time and have been used as an indicator of both serum glucose levels and oxidative protein damage. Elevated serum CML modified proteins have been associated with diabetes and may contribute to diabetic retinopathy, nephropathy and angiopathy. | | | Catalog # | A0909-75E | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilutions | ELISA: 1:2500-1:20,000 | | Western Blot: 1:2500-1:20,000 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | N/A | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Concentration | ~1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 1mM EDTA, 0.02% sodium azide. | | Purity | Purified by affinity chromatography. | | Immunogen | Carboxymethyllysine (KLH) | | Specificity | Recognizes Carboxymethyllysine-modified proteins. | | Species Crossreactivity | All species | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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