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Anti -AFAP (actin filament associated protein 1, actin filament associated protein, AFAP, AFAP-110, FLJ56849)
Anti -AFAP (actin filament associated protein 1, actin filament associated protein, AFAP,
AFAP-110, FLJ56849)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
B |
|
| AFAP (actin filament associated protein; also known as AFAP-110) is an adaptor protein that regulates actin filament integrity. It is both multimodular and multimeric, and is known to simultaneously bind actin and cytosolic kinases. As a homomultimer, AFAP binds and separates actin filaments, preventing actin cross-linking. Upon binding to kinases, AFAP is destabilized, promoting actin polymerization. Human AFAP is 730aa in length, and contains SH3 and SH2 binding motifs (aa69-74 and aa91-96), two pleckstrin homology domains (aa153-248 and | | | aa347-450) and a Leu-zipper/actin binding region (aa511-637). Over aa450-730, human AFAP is 86% identical to mouse and rat AFAP. | | | | | | Applications: | | | Suitable for use in Western Blot. Other applications not tested. | | | Catalog # | A0923-75 | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Goat | | Source | Human | | Concentration | As reported | | Form | Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS with 5% trehalose. Reconstitute with 40-50% glycerol, PBS. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Recombinant human AFAP aa450-730 (E. coli). | | Specificity | Recognizes human AFAP. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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