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You are here:Home » Antibodies » Abs to Obesity Proteins » Anti -AGRP (Agouti-related Protein, AGRT, ART)

Anti -AGRP (Agouti-related Protein, AGRT, ART)


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Clone Host Grade Applications
Polyclonal Goat Affinity Purified E
AGRP, secreted hypothalamic factors regulated by the metabolic state in mammals, is involved in energy homeostasis and plays an important role in the control of feeding behavior. Agouti protein and Agouti-related protein are paracrine-signaling molecules that normally regulate pigmentation and body weight. The mature human protein is a single polypeptide chain of 112aa residues consisting of an N-terminal acidic region and a unique C-terminal cysteine-rich domain. Circular dichroism studies indicated that the purified protein contains primarily random coil and beta-sheet secondary structure. The hypothalamic expression of AGRP is regulated by leptin, and overexpression of AGRP in transgenic animals results in obesity and diabetes.
Catalog #A1059-62N
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionPeptide ELISA: 1:32,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
FormSupplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to CRKLGTAMNPCSRT, from the C-terminus of the protein sequence according to NP_001129.1.
SpecificityRecognizes AGRP. Species sequence homology: chimpanzee, canine, human, mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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