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You are here:Home » Antibodies » Abs to Obesity Proteins » Anti -AgRP (Agouti Related Protein, Agouti-related Transcript, AGRT, ART, ASIP2, MGC118963)

Anti -AgRP (Agouti Related Protein, Agouti-related Transcript, AGRT, ART, ASIP2,
MGC118963)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum IH IF
Agouti is a paracrine-signaling molecule that affects pigmentation by inhibiting the melanocortin receptor 1 (MCR-1). However, recombinant Agouti protein also antagonizes the MC2R and MC4R. AGRP (132 aa in human, chromosome 16q21) is normally expressed in adrenal and hypothalamus. AGRP levels are increased several folds in ob/ob mice. AGRP is a strong antagonist of MC3R and MC4R. Ubiquitous expression of AGRP in transgenic mice causes obesity without altering skin pigmentation.
Catalog #A1059-62U
ApplicationsSuitable for use in Immunohistochemistry and Immunofluorescence. Other applications not tested.
Recommended DilutionImmunofluorescence: 1:200
Immunohistochemistry (PAP or ABC): 1:500
Optimal dilutions to be determined by the researcher.
AA SequenceSer-Pro-Arg-Arg-Cys-Val-Arg-Leu-His-Glu-Ser-Cys-Leu-Gly-Gln-
Gln-Val-Pro-Cys-Cys-Asp-Pro-Cys-Ala-Thr-Cys-Tyr-Cys-Arg-Phe-
Phe-Asn-Ala-Phe-Cys-Tyr-Cys-Arg-Lys-Leu-Gly-Thr-Ala-Thr-Asn-
Leu-Cys-Ser-Arg-Thr-NH2 (Five S - S bonds formed, disulfide bridges undetermined)
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationNot determined
FormSupplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O.
PuritySerum
ImmunogenSynthetic peptide corresponding aa82-131 of mouse AGRP.
SpecificityRecognizes mouse AGRP. Species crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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