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Anti -AgRP (Agouti Related Protein, Agouti-related Transcript, AGRT, ART, ASIP2, MGC118963)
Anti -AgRP (Agouti Related Protein, Agouti-related Transcript, AGRT, ART, ASIP2,
MGC118963)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Serum |
IH IF |
|
| Agouti is a paracrine-signaling molecule that affects pigmentation by inhibiting the melanocortin receptor 1 (MCR-1). However, recombinant Agouti protein also antagonizes the MC2R and MC4R. AGRP (132 aa in human, chromosome 16q21) is normally expressed in adrenal and hypothalamus. AGRP levels are increased several folds in ob/ob mice. AGRP is a strong antagonist of MC3R and MC4R. Ubiquitous expression of AGRP in transgenic mice causes obesity without altering skin pigmentation. | | | Catalog # | A1059-62U | | Applications | Suitable for use in Immunohistochemistry and Immunofluorescence. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 1:200 | | Immunohistochemistry (PAP or ABC): 1:500 | | Optimal dilutions to be determined by the researcher. | | AA Sequence | Ser-Pro-Arg-Arg-Cys-Val-Arg-Leu-His-Glu-Ser-Cys-Leu-Gly-Gln- | | Gln-Val-Pro-Cys-Cys-Asp-Pro-Cys-Ala-Thr-Cys-Tyr-Cys-Arg-Phe- | | Phe-Asn-Ala-Phe-Cys-Tyr-Cys-Arg-Lys-Leu-Gly-Thr-Ala-Thr-Asn- | | Leu-Cys-Ser-Arg-Thr-NH2 (Five S - S bonds formed, disulfide bridges undetermined) | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | N/A | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Mouse | | Concentration | Not determined | | Form | Supplied as a lyophilized powder. Reconstitute with 50ul sterile ddH2O. | | Purity | Serum | | Immunogen | Synthetic peptide corresponding aa82-131 of mouse AGRP. | | Specificity | Recognizes mouse AGRP. Species crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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