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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -Ah Receptor (Aryl Hydrocarbon Receptor, AHR)

Anti -Ah Receptor (Aryl Hydrocarbon Receptor, AHR)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites B IP IH
The aryl hydrocarbon receptor (AhR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AhR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the Ah Receptor.
Studies indicate that in non-ligand activated cells, AhR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). The AhR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1.
Catalog #A1059-72Y
ApplicationsSuitable for use in Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Paraffin): 1:100. Staining of rat liver results in strong cytoplasmic and some nuclear staining.
Immunoprecipitation: A single ~95kD protein representing AHR from Hepa 1 cytosol.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG
Clone No8J216
HostMouse
SourceMouse
ConcentrationNot Determined
FormSupplied as a liquid, 0.05% sodium azide.
PurityAscites
ImmunogenSynthetic peptide corresponding to amino acid 12-31, (12)RKRRKP(17)V(22)KPIPAEGIK(31) from mouse AHR protein with amino acids 18-21 omitted.
SpecificityRecognizes mouse Aryl Hydrocarbon Receptor (AHR). Species Crossreactivity: human and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesDioxin Receptor


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