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Anti -Ah Receptor (Aryl Hydrocarbon Receptor, AHR)
Anti -Ah Receptor (Aryl Hydrocarbon Receptor, AHR)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
B |
|
| The Aryl Hydrocarbon Receptor (AHR), also known as the dioxin receptor, is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AH Receptor. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AHR is believed to transform to a nuclear, DNA binding form. This transformation process appears to involve dissociation of HSP90 from AHR followed by formation of a heterodimer with AHR nuclear translocator protein (Arnt). The AHR-ligand complex appears to initiate gene transcription of cytochrome P450 1A1. | | | Catalog # | A1059-72Z | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilutions | Western Blot: 1:1000. Detects an ~95kD protein representing AhR from Hepa 1 cytosol. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 8J217 | | Host | Mouse | | Source | Mouse | | Concentration | Not Determined | | Form | Supplied as a liquid, 0.05% sodium azide | | Purity | Ascites | | Immunogen | Synthetic peptide corresponding to aa12-31. RKRRKP(17)V(22)KPIPAEGIK from the mouse AhR protein with aa18-21 omitted. | | Specificity | Recognizes mouse Aryl hydrocarbon receptor. Species Crossreactivity: human and rat | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | Dioxin Receptor |
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