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You are here:Home » Molecular Biology » MB-Enzymes » AHCY, N-terminal GST-Tag, Recombinant, Human (Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, SAHH)

AHCY, N-terminal GST-Tag, Recombinant, Human (Adenosylhomocysteinase, AdoHcyase,
S-adenosyl-L-homocysteine hydrolase, SAHH)

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Specifications

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Catalog #A1059-73C
AHCY deficiency is one of the causes of hypermethioninemia, a rare disease affecting brain development and muscle strength. Down-regulation of AHCY is also associated with certain forms of cancer, Huntington's disease and Wilson's disease.
SourceRecombinant corresponding to aa2-end of human AHCY with N-terminal GST tag expressed in E. coli (NM_000687).
ApplicationsSuitable for use in enzyme kinetics, inhibitor screening and selectivity profiling. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityAliquot to avoid repeated freezing and thawing. Store at -70°C. Aliquots are stable for at least 6 months at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight73kD
SourceE. coli
PurityPurified 90%
FormSupplied as a liquid in 25mM Tris-HCl, pH 8.0, 100mM sodium chloride, 0.05% tween-20, 3mM DTT, 20% glycerol.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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