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You are here:Home » Molecular Biology » MB-Apoptosis » Apoptosis Inducing Factor (IN) Blocking Peptide ((AIF, MGC111425, Programmed cell death protein 8, mitochondrial precursor, PDCD8)

Apoptosis Inducing Factor (IN) Blocking Peptide ((AIF, MGC111425, Programmed cell death
protein 8, mitochondrial precursor, PDCD8)

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Specifications

Peptide corresponding to amino acids 517 to 531 of human AIF (2).
Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins (1). A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF) (2). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed (2).
Catalog #A1059-75P
SourceSynthetic peptide
PurityPurified 60-70%
Concentration0.2mg/ml
FormSupplied as a lyophilized powder.
Important NoteThis product is intended for research use only, not for use in human, therapeutic or diagnostic applications.


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