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You are here:Home » Antibodies » Abs to Apoptosis » Anti -Apoptosis Inducing Factor (AIF, MGC111425, Programmed cell death protein 8, mitochondrial precursor, PDCD8)

Anti -Apoptosis Inducing Factor (AIF, MGC111425, Programmed cell death protein 8,
mitochondrial precursor, PDCD8)


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Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IP IH IC FC IF
AIF, or apoptosis-inducing factor, is a flavoprotein localized to the mitochondrial membrane that plays a primary role in caspase-independent cell death, or apoptosis (1,2). AIF translocates to the nucleus when apoptosis is induced and causes mitochondria to release the apoptogenic proteins, cytochrome c and caspase-9. Apoptotic activity of AIF leads to chromatin condensation and DNA fragmentation (1). Similar to cytochrome c, AIF is a bifunctional protein with an oxidoreductase function and a second apoptogenic function. In contrast to cytochrome c, however, AIF acts in a caspase-independent fashion (2,3,4).
Catalog #A1059-75Q
ApplicationsSuitable for use in Immunofluorescence, Western Blot, Flow Cytometry, Immunoprecipitation, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Immunohistochemistry: 1:500
Immunocytochemistry: 1:500
Flow Cytometry: 1:50
Immunoprecipitation: 1:10
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
Clone No6k14
ConcentrationNot determined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.05% BSA 0.01% sodium azide, 40% glycerol.
ImmunogenA synthetic peptide correspndonding to residues near the C-terminus of Human AIF
SpecificityRecognizes human AIF at 67kD. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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