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You are here:Home » Antibodies » Abs to Apoptosis » Anti -Apoptosis Inducing Factor (NT) (AIF, MGC111425, Programmed cell death protein 8, mitochondrial precursor, PDCD8)

Anti -Apoptosis Inducing Factor (NT) (AIF, MGC111425, Programmed cell death protein 8,
mitochondrial precursor, PDCD8)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Highly Purified B
Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins (1). A novel gene, the product of which causes chromatin condensation and DNA fragmentation, was recently identified, cloned, and designated apoptosis inducing factor (AIF) (2). Like the critical molecules, cytochrome c and caspase-9, in apoptosis, AIF localizes in mitochondria. AIF translocates to the nucleus when apoptosis is induced and induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. AIF induces chromatin condensation and DNA fragmentation, which are the hallmarks of apoptosis, of the isolated nucleus and the nucleus in live cells by microinjection. AIF is highly conserved between human and mouse and widely expressed (2).
Catalog #A1059-76
This polyclonal antibody can be used for detection of AIF by Western blot at 0.25 to 1ug/ml. K562 cell lysate can be used as positive control and a 67kD band should be detected.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PuritySupplied as chromatographically purified IgG
ImmunogenAIF (NT)
SpecificityRecognizes human and mouse AIF (NT)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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