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You are here:Home » Antibodies » Abs to Actin Related Proteins » Anti -AIF1 (Allograft Inflammatory Factor 1, AIF-1, DASS-82G15.2, G1, IBA1, IRT-1, Em:AF129756.17, Interferon gamma Responsive Transcript, IRT-1, Ionized Calcium-binding Adapter Molecule, Protein G1)

Anti -AIF1 (Allograft Inflammatory Factor 1, AIF-1, DASS-82G15.2, G1, IBA1, IRT-1,
Em:AF129756.17, Interferon gamma Responsive Transcript, IRT-1, Ionized Calcium-binding
Adapter Molecule, Protein G1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified E B
AIF-1 is a 17kD IFN-gamma inducible Ca2+-binding EF-hand protein, associated with chronic inflammatory processes. AIF-1 is constitutively expressed in lymphatic tissue and is up-regulated in monocytes/macrophages under various pathological conditions such as chronic rejection of allografts and in autoimmune lesions. In the brain, a subset of microglial cells constitutively express AIF-1. Increased numbers of AIF-1 immunoreactive macrophage/microglial cells were observed in focal brain infarctions, traumatic brain injury, gliomas, uveitis and in inflammatory lesions of a rat model of autoimmune disease, autoimmune encephalomyelitis and neuritis. Several Ca2+-binding peptides have been associated with monocyte activation, in particular members of the S-100 supergene-family. AIF-1 is a Ca2+-binding peptide which is not a member of the S-100 gene cluster but is located within the HLA class III genomic region.
Catalog #A1059-86
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1, k
Clone No2A2-B6
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified.
ImmunogenAIF1 (AAH09474, 1-148aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
SpecificityRecognizes human AIF1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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