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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -AIRE (APECED, APS1, APSI, Autoimmune Regulator, PGA1, Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein)

Anti -AIRE (APECED, APS1, APSI, Autoimmune Regulator, PGA1, Autoimmune Polyendocrinopathy
Candidiasis Ectodermal Dystrophy Protein)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Catalog #A1059-88A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:64,000.
Western Blot: 0.3-1ug/ml. ~ 55kDa band observed in Human Spleen lysates (calculated MW of 57.7kDa according to NP_000374.1).
Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris-saline, pH7.2, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide, C-KAKPPKKPESSAEQ, representing the internal region of the human protein according to NP_000374.1; NP_000649.1. Homology
SpecificitySpecies Crossreactivity: Human. Other species not tested.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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