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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -AIRE (Autoimmune Regulator, Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein, APECED Protein, APECED) (PE)

Anti -AIRE (Autoimmune Regulator, Autoimmune Polyendocrinopathy Candidiasis Ectodermal
Dystrophy Protein, APECED Protein, APECED) (PE)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified FC
AIRE (Autoimmune Regulator; also APECED) is a 58-60kD transcriptional regulator that exhibits tightly regulated expression. It is widely expressed in lymphoid organs, but is most pronounced in thymic medullary epithelium, where it induces the expression of organ-specific antigens that are used to sequester and delete autoreactive lymphocytes. Mouse AIRE is 552aa in length. It contains multiple domains, including an HSR domain with two LXXLL motifs aa1-106, an NLS aa114-134, one SAND domain aa182-282 and two PHD zinc finger regions aa98-345; 434-475. AIRE will homodimerize and tetramerize. There are multiple potential isoforms that involve various combinations of deletions of aa265-268, 368-426 and aa296, plus a 42 a substitution for aa368-552. Over aa476-552, mouse AIRE shares 91% and 65% aa identity with rat and human AIRE.
Catalog #A1059-88T
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Excitation 488nm
Emission 565-605nm
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2A
Clone No12K6
HostRat
SourceMouse
ConcentrationNot determined
FormSupplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
PurityPurified by Protein G affinity chromatography.
ImmunogenRecombinant corresponding to aa476-552 from mouse AIRE expressed in E.coli.
SpecificityRecognizes mouse AIRE.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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