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AHSP, Recombinant Human (Alpha-hemoglobin-stabilizing protein, EDRF, ERAF, Erythroid associated factor, Erythroid differentiation-related factor)
AHSP, Recombinant Human (Alpha-hemoglobin-stabilizing protein, EDRF, ERAF, Erythroid
associated factor, Erythroid differentiation-related factor)
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| AHSP (Alpha-hemoglobin stabilizing protein), also known as ERAF (Erythroid associated factor), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of aplha-hemoglobin during normal erythroid cell development. It specifically protects free alpha-hemoglobin from precipitation in live cells and in solution. This protein is downregulated in transmissible spongiform encephalopathies (TSEs). It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Recombinant AHSP protein, expressed in E. coli and purified by using conventional chromatography techniques. | | | Catalog # | A1061 | | Source | Recombinant corresponding to human AHSP, 1aa-102, expressed in E. coli. | | AA Sequence | MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Aliquot to avoid repeated freezing and thawing and freeze at -70°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months. | | Molecular Weight | 11.8kD | | Source | E.coli | | Purity | ~95% (SDS-PAGE) Purified by immunoaffinity chromatography. | | Concentration | ~1mg/ml | | Form | Supplied as liquid in 20 mM Tris-HCl buffer, pH 8.0, 10% glycerol. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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