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Anti -Akirin2, IN1 (C6orf166, chromosome 6 open reading frame 166, dJ486L4.2, FBI1, FLJ10342, Protein C6orf166, Uncharacterized protein C6orf166)
Anti -Akirin2, IN1 (C6orf166, chromosome 6 open reading frame 166, dJ486L4.2, FBI1,
FLJ10342, Protein C6orf166, Uncharacterized protein C6orf166)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death. | | | Catalog # | A1105-81 | | Applications | Suitable for use in Elisa and Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 1-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Mouse Brain Tissue Lysate | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to 15aa from near the center of the human Akirin2. | | Specificity | Recognizes human Akirin2. Species Crossreactivity: Mouse. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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