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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified B

The serine-threonine kinase Akt, also known as protein kinase B (PKB), is an important effector for phosphatidylinositol 3-kinase signaling, initiated by numerous growth factors and hormones. Three mammalian isoforms (Akt1/PKBa, Akt2/PKBb, and Akt3/PKBg) have been cloned. Akt2 and Akt3 have 81% and 83% homology in aa sequences with Akt1, respectively. Numerous studies have revealed that the expression pattern of Akt1 and Akt2 is ubiquitous, whereas Akt3 is expressed predominantly in the brain, heart, and kidneys. Akt has a pivotal role in cell cycle progression, inhibition of apoptosis and cell growth.
Catalog #	A1124-12H
Applications	Suitable for use in Western Blot. Other applications not tested.
Recommended Dilution	Western Blot: 0.5-2ug/ml
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Source	Human
Concentration	~0.1mg/ml
Form	Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
Purity	Purified by immunoaffinity chromatography.
Immunogen	Synthetic peptide surrounding aa100 of the human Akt2.
Specificity	Recognizes human Akt2. Species Crossreactivity: mouse.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.