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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -AKT1 (RAC-alpha Serine/Threonine-protein Kinase, Protein Kinase B, PKB, Proto-oncogene c-Akt, RAC-PK-alpha, PKB, RAC)

Anti -AKT1 (RAC-alpha Serine/Threonine-protein Kinase, Protein Kinase B, PKB,
Proto-oncogene c-Akt, RAC-PK-alpha, PKB, RAC)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
AKT, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The major activity of AKT/PKB is to mediate cell survival. AKT/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and AKT/PKB kinase activity. AKT/PKB phosphorylation is critical for it activity. The major phosphorylation sites required for AKT activation has been identified as threoinine 308 and serine 473. Serine 473 is phosphorylated by MAPKAP kinase 2.
Catalog #A1125-05Q
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlJurkat
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in PBS, 0.1mg/ml BSA, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa464-477 of human AKT1.
SpecificityRecognizes human AKT1. Species sequence homology: chicken, frog, mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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