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You are here:Home » Molecular Biology » MB-Protein Kinases » Akt2, Rat, Control Peptide (AKT-2, Protein Kinase Akt2, Protein Kinase B beta, PKB beta, PKBBeta, PRKBB, Rac Protein Kinase beta, RAC-BETA, RAC-beta Serine/threonine Protein Kinase, RAC-PK-beta, v-AKT Murine Thymoma Viral Oncogene Homolog 2)

Akt2, Rat, Control Peptide (AKT-2, Protein Kinase Akt2, Protein Kinase B beta, PKB beta,
PKBBeta, PRKBB, Rac Protein Kinase beta, RAC-BETA, RAC-beta Serine/threonine Protein
Kinase, RAC-PK-beta, v-AKT Murine Thymoma Viral Oncogene Homolog 2)

Pricing

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Specifications

A 16-aa peptide near the C-terminus of rat AKT2.
Catalog #A1125-28C
Putative human homologs of the protooncogene v-akt of the acutely transforming retrovirus AKT8 have been cloned. These protein-serine/threonine kinase proteins have a catalytic domain closely related to both PKA and PKC and have been designated rac (related to A and C kinases), pkb (Protein kinase B) or Akt. RAC protein kinase family members feature pleckstrin homology (PH) domain at the amino terminus and a protein-serine/threonine kinase catalytic domain at the carboxy terminus. The Amino terminal domain (referred to as AH-Akt Homology domain) spans from 1-148 amino acids and contains the PH domain, a region found in diverse group of signaling proteins. The PH domain (amino acids 1-106) has been implicated in interactions with other proteins such as G-protein bg subunits, as well as phosphoinositides. The kinase domain is located between residues 148 to 411. These enzymes are activated by diverse ligands such as PGDF, EGF and basic FG in NIH 3T3, Rat-1 or Swiss-3T3 cells.
AKT2 (RAC-PK-b;) has been shown to be amplified and over-expressed in some human carcinoma cell lines and primary tumors suggesting that it may contribute to the development of common epithelial tumors of the ovary (3). It has been reported that anti-sense AKT2 can greatly inhibit the expression of AKT2 protein and suppress the tumorogenic phenotype of PANC1 cells inoculated s.c. in nude mice. This effect was restricted to cells that over-express AKT2. It is postulated that over-expression of AKT2 could upregulate the mediation of growth signals that may contribute to cell proliferation.
SourceRat
PurityHighly purified
Concentration1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 0.1% sodium azide
SpecificityThe rat control peptide is 93% conserved in mouse and human AKT2. No significant homology is seen with AKT1 or AKT3 or other kinases. Antibody crossreactivity in various species is not established. Control peptide, because of its low MW (<3kD), is not suitable for Western. It should be used for ELISA or antibody blocking to confirm antibody specificity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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