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You are here:Home » Antibodies » Abs to Enzymes, Dehydrogenase » Anti -ALDH5A1 (Succinate-semialdehyde Dehydrogenase, Mitochondrial, Aldehyde Dehydrogenase Family 5 Member A1, NAD(+)-dependent Succinic Semialdehyde Dehydrogenase, SSADH)

Anti -ALDH5A1 (Succinate-semialdehyde Dehydrogenase, Mitochondrial, Aldehyde Dehydrogenase
Family 5 Member A1, NAD(+)-dependent Succinic Semialdehyde Dehydrogenase, SSADH)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA). Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.
Catalog #A1334-36Q
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 0.3-1ug/ml, human liver lysates observed on ~55kD bands
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to C-SQDPAQIWRVAE, from ALDH5A1, at the internal region of the protein (NP_733936.1 NP_001071.1).
SpecificityRecognizes ALDH5A1. Species Crossreactivity
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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