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You are here:Home » Antibodies » Abs to Enzymes, Dehydrogenase » Anti -Aldo-Keto Reductase Family 1 Member C4 (AKR1C4, HGNC:387, 3-alpha-HSD, C11, CDR, CHDR, DD4, HAKRA, MGC22581, 3-alpha Hydroxysteroid Dehydrogenase Type I, 3 alpha-Hydroxysteroid Dehydrogenase, 3-alpha-Hydroxysteroid Dehydrogenase Variant, Chlordecone Reduc

Anti -Aldo-Keto Reductase Family 1 Member C4 (AKR1C4, HGNC:387, 3-alpha-HSD, C11, CDR,
CHDR, DD4, HAKRA, MGC22581, 3-alpha Hydroxysteroid Dehydrogenase Type I, 3
alpha-Hydroxysteroid Dehydrogenase, 3-alpha-Hydroxysteroid Dehydrogenase Variant,
Chlordecone Reduc

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified E B
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Catalog #A1334-70U
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:4000
Western Blot: 0.1-0.3ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostGoat
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to human AKR1C4.
SpecificityRecognizes human AKR1C4 at ~35kD in human liver lysates (calculated MW of 37.1kDa according to NP_001809.2). This antibody may cross-react with AKR1C1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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