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You are here:Home » Antibodies » Abs to Disease Markers » Anti -ALS2 (Alsin, Amyotrophic Lateral Sclerosis Protein 2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 6 Protein, KIAA1563, ALS2CR6)

Anti -ALS2 (Alsin, Amyotrophic Lateral Sclerosis Protein 2, Amyotrophic Lateral Sclerosis
2 Chromosomal Region Candidate Gene 6 Protein, KIAA1563, ALS2CR6)

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified IH
ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in its gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis.
Catalog #A1362-85C
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 3-5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to LKACYYQIQREKLN, from the C-terminus of the protein sequence according to NP_065970.2.
SpecificityRecognizes human ALS2. Species sequence homology: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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