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You are here:Home » Antibodies » Abs to Disease Markers » Anti -Amyotrophic lateral sclerosis protein 2 (ALS2)

Anti -Amyotrophic lateral sclerosis protein 2 (ALS2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
Amyotrophic lateral sclerosis protein 2 (ALS2) or Alsin is a 184kD protein that contains three guanine-nucleotide exchange factor domains and may act as a GTPase regulator. ALS2 dysfunction affects endosome trafficking through a Rab5 small GTPases family-mediated mechanism. It is a causative gene for a juvenile autosomal recessive form of motor neuron diseases, including amyotrophic lateral sclerosis 2. This disorder is characterized by a progressive degeneration of the upper motor neurons of the motor cortex and the lower motor neurons of the brain stem and spinal cord.
Catalog #A1362-86
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, pH 7.2.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide (LKACYYQIQREKLN) corresponding to aa1644-1657 of human ALS2
SpecificityRecognizes human ALS2
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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