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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -ALS2CR2, CT (L289) (STE20-related Kinase Adapter Protein beta, STRAD beta, Pseudokinase ALS2CR2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein, ILP-interacting Protein, CALS-21, STRADB, ILPIP, PRO1038)

Anti -ALS2CR2, CT (L289) (STE20-related Kinase Adapter Protein beta, STRAD beta,
Pseudokinase ALS2CR2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2
Protein, ILP-interacting Protein, CALS-21, STRADB, ILPIP, PRO1038)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B
ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2.
Catalog #A1363-10F
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:1,000
Western Blot: 1:50-1:100
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.09% sodium azide.
PurityPurified by ammonium sulfate precipitation.
ImmunogenSynthetic peptide selected from the C-terminal region of human ALS2CR2 (KLH).
SpecificityRecognizes human ALS2CR2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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