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Anti -ALS2CR2, NT (STE20-related Kinase Adapter Protein beta, STRAD beta, Pseudokinase ALS2CR2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein, ILP-interacting Protein, CALS-21, STRADB, ILPIP, PRO1038)
Anti -ALS2CR2, NT (STE20-related Kinase Adapter Protein beta, STRAD beta, Pseudokinase
ALS2CR2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein,
ILP-interacting Protein, CALS-21, STRADB, ILPIP, PRO1038)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Purified |
E B |
|
| ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2. | | | Catalog # | A1363-10G | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilution | ELISA: 1:1,000 | | Western Blot: 1:50-1:100 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.25mg/ml | | Form | Supplied as a liquid in PBS, 0.09% sodium azide. | | Purity | Purified by ammonium sulfate precipitation. | | Immunogen | Synthetic peptide selected from the N-terminal region of human ALS2CR2 (KLH). | | Specificity | Recognizes human ALS2CR2. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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