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Anti -ALS2CR2, CT (STE20-related Kinase Adapter Protein beta, STRAD beta, Pseudokinase ALS2CR2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein, ILP-interacting Protein, CALS-21, STRADB, ILPIP, PRO1038)
Anti -ALS2CR2, CT (STE20-related Kinase Adapter Protein beta, STRAD beta, Pseudokinase
ALS2CR2, Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 2 Protein,
ILP-interacting Protein, CALS-21, STRADB, ILPIP, PRO1038)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Goat |
Affinity Purified |
E B IH |
|
| ALS2CR2 potentiates the antiapoptotic activity of XIAP by enhancing XIAP-mediated activation of JNK1 (MAPK8) and other JNK family members, but not by modulating XIAP-mediated caspase inhibition. Expression of a catalytically inactive TAK1 (MAP3K7) mutant blocks the XIAP/ALS2CR2 activation of JNK1. In vivo coprecipitation experiments show that both ALS2CR2 and XIAP interact with TAK1 and TRAF6. It has been proposed that XIAP-mediated protection from apoptosis utilizes both a JNK1 activation pathway that involves ALS2CR2 and a caspase inhibition pathway that is independent of ALS2CR2. | | | Catalog # | A1363-10N | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 1:32,000 | | Western Blot: 1-3ug/ml | | Immunohistochemistry (Formalin-fixed, paraffin-embedded): 3.75ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Host | Goat | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | | Immunogen | Synthetic peptide corresponding to CDFPDEKDSYWEF from the C-terminal of human ALS2CR2. | | Specificity | Recognizes human STRADB. Species sequence homology: canine | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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