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You are here:Home » Antibodies » Abs to Disease Markers » Anti -Alzheimer Precursor Protein A4

Anti -Alzheimer Precursor Protein A4

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified B IH IF
Deposits of amyloid protein in senile plaques near nerve processes are found in the brains of aged humand and cases of Alzheimer's Disease. The principle component of this extracellular amyloid is beta/A4, a 4 kDa peptide derived from a larger amyloid precursor protein (APP), which is widely expressed in the brain and body. The creation, transport and function of these proteins are currently under investigation.
Catalog #A1372-19
ApplicationsSuitable for use in Immunofluorescence, Immunohistochemistry and Western Blot. Other applications not tested.
Recommended DilutionsImmunohistochemistry: 5-10ug/ml on 4% paraformaldehyde/15% picric acid perfused and fixed rat spinal cord. Also good for paraffin-embeddedd tissues at 1:10- 1:20.
Western Blot: 10ug/ml under reducing conditions.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2Q12
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.6, 0.1% sodium azide.
PurityPurified
ImmunogenPurified recombinant Alzheimer precursor A4 (pre A4695) fusion protein (66-81aa). Epitope: N-terminus.
SpecificityRecognizes a N-terminal epitope on the human pre-A4 molecule. Species Crossreactivity: canine, fish, rat, mouse, monkey and porcine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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