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You are here:Home » Antibodies » Abs to Enzymes, Decarboxylase » Anti -AMD1 (SAMDC , S-adenosylmethionine Decarboxylase Proenzyme, AdoMetDC, S-adenosylmethionine Decarboxylase alpha Chain, S-adenosylmethionine Decarboxylase beta Chain, AMD1, AMD)

Anti -AMD1 (SAMDC , S-adenosylmethionine Decarboxylase Proenzyme, AdoMetDC,
S-adenosylmethionine Decarboxylase alpha Chain, S-adenosylmethionine Decarboxylase beta
Chain, AMD1, AMD)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
S-adenosylmethionine decarboxylase (AdoMet-DC), also known as S-adenosylmethionine decarboxylase proenzyme (SAMDC), is a key enzyme in polyamine biosynthesis. It is localized to chromosome region 6q21-q22. SAMDC has an unusual distribution in polysomes from cells of T lymphocyte origin. It associates predominantly with monosomes and small polysomes with none located in the preribosomal or ribonucleoprotein pool. SAMDC is a critical regulatory enzyme of the polyamine synthetic pathway, and a well-studied drug target. Since SAMDC is a key regulatory enzyme in the synthesis of spermidine and spermine, the marked increase in SAMDC activity in the neonate and the sustained high enzyme levels throughout adulthood, imply a role for these polyamines in both development and mature brain function.
Catalog #A1372-24C
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsWestern Blot: 0.1-0.5ug/ml
Immunohistochemistry (Paraffin): 0.5-1ug/ml. Antigen retrieval by heat is required.
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH20. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder from PBS, pH 7.4, 5% BSA, 0.05% thimerosal, 0.05% sodium azide. Reconstitute with 200ul sterile ddH2O.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa315-330, FNDYNFVFTSFAKKQQ at C-terminal of human AMD1, identical to the related mouse and rat sequence.
SpecificityRecognizes human AMD1. Species Crossreactivity: mouse and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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