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You are here:Home » Antibodies » Abs to Autophagy » Anti -AMBRA1 (Activating Molecule in BECN1-regulated Autophagy Protein 1, KIAA1736)

Anti -AMBRA1 (Activating Molecule in BECN1-regulated Autophagy Protein 1, KIAA1736)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Ambra1, a WD40 domain containing protein, is a novel activating molecule in Beclin 1-regulated autophagy and plays a role in the development of the nervous system. The protein binds to Beclin 1 and favors Beclin 1/Vps34 interaction. The Ambra1 gene localized on human chromosome 11p11.2, encodes the protein that is highly conserved in vertebrates only and its expression is mostly confined to the neuroepithelium during early neurogenesis.
Catalog #A1372-28
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman brain lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa1-50 of human Ambra1.
SpecificityRecognizes human Ambra1. Species Crossreactivity: chicken, bovine, mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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