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You are here:Home » Antibodies » Abs to Connexin, Junction Proteins » Anti -AMICA (Adhesion Molecule that Interacts with CXADR Antigen 1, Junction Adhesion Molecule-Like, JAM-L, JAML)

Anti -AMICA (Adhesion Molecule that Interacts with CXADR Antigen 1, Junction Adhesion
Molecule-Like, JAM-L, JAML)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
AMICA (Adhesion Molecule that interacts with CXADR antigen 1), also known as junction adhesion molecule like (JAM-L) is a 60kD type I transmembrane glycoprotein member of the JAM family of adhesion molecules. Human AMICA has an extracellular domain (ECD) of 275 amino acids (aa) and a cytoplasmic tail of 98 amino acids. The ECD contains two Ig-like regions. There is an N-terminal C2-type Ig-like domain and a membrane proximal V-type Ig-like domain. AMICA is expressed by leukocytes and is concentrated at areas of cell-cell contact. It forms noncovalent homodimers on the cell surface and binds CXADR on epithelial cells. Two splice variants apparently exist that only involve the first 40 aa of the precursor. Human AMICA ECD is 62% and 76% aa identical to mouse and dog AMICA ECD, respectively.
Catalog #A1372-37
ApplicationsSuitable for use in Western Blot and ELISA. Other applications not tested.
Recommended DilutionWestern Blot: 1-2ug/ml
ELISA: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No7H215
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile ddH2O or sterile 40-50% glycerol.
PurityPurified by Protein G affinity chromatography.
ImmunogenNS0-derived recombinant human AMICA (aa10-265) Accession # Q86YT9
SpecificityRecognizes human AMICA.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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