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A1378-37 5-Aminolevulinic Acid, Hydrochloride Salt (5-ALA HCl) CAS: 5451-09-2

Specifications
References
CAS Number
5451-09-2
Grade
Highly Purified
MDL Number
MFCD00012869
Molecular Formula
C5H10ClNO3
Molecular Weight
167.59
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
5-Amino-4-oxopentanoic Acid Hydrochloride; δ-Aminolevulinic Acid Hydrochloride; Aminolevulinic Acid Hydrochloride; 5-ALA HCl; Levulan

Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer). 5-ALA is used in photodynamic therapy due to its properties as a photosensitizer, with applications in treatment of acne. 5-Aminolevulinic acid hydrochloride is used for visualisation of tumorous tissue in neurosurgical procedures enabling a reduction in the tumor residual volume and prolongation of progression-free survival in people with malignant gliomas. 5-ALA also has potential applications in diagnostic oncology in detection of bladder cancer

Synonyms
5-Amino-4-oxopentanoic Acid Hydrochloride; δ-Aminolevulinic Acid Hydrochloride; Aminolevulinic Acid Hydrochloride; 5-ALA HCl; Levulan
CAS No
5451-09-2 Free Base: 106-60-5
Molecular Formula
C5H10ClNO3
Molecular Weight
167.59
Appearance
White to off-white powder
Purity
≥97% (HPLC)
Melting Point
145-155°C (subl)
Heavy Metals
≤0.002%
Iron (Fe)
≤0.002%
Loss on Drying
≤1%
Residue on Ignition
≤0.5%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Sisler, E.C., et al.: Physiol. Plant., 16, 315 (1963), Herdeis, C., et al.: Arch. Pharm., 317, 304 (1984), Peng, Q., et al.: Cancer, 79, 2282 (1997)
USBio References
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