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You are here:Home » Antibodies » Abs to Transcription Factors » Anti -AML-1

Anti -AML-1

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
AML-1 is a DNA-binding protein which specifically interacts with a sequence belonging to the group of enhancer core motifs, TGT/cGGT. The AML1 gene on chromosome 21 is disrupted in the (8;21)(q22;q22) translocation associated with acute myelogenous leukemia and encodes a protein with a central 118-amino-acid domain with 69% homology to the Drosophila pair-rule gene, runt. AML-1 translocation is frequently observed in acute myeloid leukemia. It is a key transactivator of tissue-specific genes of the hematopoietic and bone lineages.
Catalog #A1383-01A
Cellular Localization Nuclear
Positive Control Ramos, Raw
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormPBS containing 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenRabbit anti-AML-1 polyclonal antibody was raised against a peptide corresponding to a sequence that is homologous in AML-1 and AML-1/ETO (amino acids 231 to 245 of human origin).
SpecificitySpecies Crossreactivity: Crossreacts with Human and Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesAML1-EVI-1, AMLCR1, CBFA2, EVI-1, PEBP2A2, PEBP2aB, RUNX1, Runt-Related Transcription Factor 1 (Acute Myeloid Leukemia 1; aml1 Oncogene


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