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You are here:Home » Antibodies » Abs to Protein Kinases » Anti -AMP Activated Protein Kinase alpha1 (AMPK a1)

Anti -AMP Activated Protein Kinase alpha1 (AMPK a1)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IP IH IF
AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilised by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels.
AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. Recent studies suggest that AMPK functions as a suppressor of cell proliferation of both malignant and normal cells.
Catalog #A1475-01P4
ApplicationsSuitable for use in ELISA, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested.
Recommended DilutionsWestern Blot: 1:100-1:1,000. Detects a band of ~63kD in rat brain cell lysates.
Immunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No10B156
HostMouse
SourceDrosophila
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to 29aa within the N-terminal catalytic domain of Drosophila AMPK alpha. Species Sequence Homology: Vertebrates, Human, Mouse AND Rat
SpecificityRecognizes both the alpha 1 and the alpha 2 isoforms of Drosophila AMP-activated protein kinase (AMPK). Species sequence homology: vertebrates, human, mouse, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names5 AMP activated protein kinase catalytic alpha 1 chain, 5' AMP activated protein kinase catalytic subunit alpha 1, AAPK1, AMPK alpha 1 chain, AMPK, AMPK1, AMPKa1, HMG CoA reductase kinase, MGC33776, MGC57364, PRKAA 1, PRKAA1, Protein kinase AMP activated


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